Not likely, but possible. Each RF code takes about 105mS to transmit. I haven't tested all the various transceivers but the RR501 starts to transmit PLC after that 105mS. It takes 367mS to transmit and most RF codes result in both an address and ON or OFF. There's an apparent bug in the RR501 firmware as it reacts to the first and third copy of the RF always sending a longer DIM sequence than does a TM751 in response to a 5 copy code burst.
If your spouse sinks RF, you definitely want to avoid Z-Wave with its complex router tables that must adjust on-the-fly to such disruptions. ;-)
They transmit as long as the button is down. You should remember that, having tracked down stuck buttons.