SpywareBlaster doesn't need to be running to provide its protection, so don't worry about forgetting to load or run it. SpywareBlaster's blocking is done by registry entries (setting "kill-bits"). Download it, install it, run it, update it, enable the protection(s), and close/exit it. That's it! After that you'll only need to run it when updating or making changes, other than that you can leave it closed.