You seem to think that only an smpt server uses SMTP - but the only compromised SMTP servers I've seen in years were workstations/laptops where the idiot had compromised their workstation is a malware that installs its own SMTP engine - the laptop becomes a SMTP server sending out hundreds of emails with the infection included per minute. The malware, in every case, didn't attempt to use the internal SMTP server, it had it's own built into it.
There are many threats, I look for more than just the common ones.