I make it a point never to use acetaminophen. If a doctor suggests it, I suggest naproxen and never had a argument.
Acetaminophen is a perfect example of a drug that should never be used since there are safer drugs on the market that are just as effective. But big pharma is a significant lobby.
Dentists seem partial to ibuprofen for some reason. It is probably as safe as naproxen, though I find naproxen to work better. It was found to have the least risk and nearly got a special status with the FDA, but then mysteriously that didn't happen. (Cough cough big pharma cough cough).
One side effect of ibuprofen is erectile dysfunction. Hey, just looking out for ya. Actually that is true with all NSAIDs, but there are more studies relating it to ibuprofen.
These days, if the side effect isn't death or anal leakage, you are doing good.