Electronics Design Medicsight CAD Improved Reader Performance in CT Colonography Study

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Medicsight CAD Improved Reader Performance in CT Colonography Study CAD Outsourcing Services 12-23-06
Posted by CAD Outsourcing Services on December 23, 2006, 7:45 am
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LONDON =E2=80=94 Medicsight plc, a subsidiary of Medicsight, Inc., announced
the publication in the December 2006 issue of Gastroenterology of a
study that showed Medicsight CAD (computer-aided detection)
significantly improved reader interpretation of CT colonography. The
paper was published with a directed editorial.

The study investigated the effect of CAD assistance on the performance
of 10 readers who were =E2=80=98non-expert=E2=80=99 in the interpretation o=
f CT
colonography. While there have been several studies of CAD performance
in isolation, this was the largest study to investigate the effect of
CAD on readers=E2=80=99 interpretation of CT colonography. The study was
performed by professor Steve Halligan and colleagues from University
College Hospital London and the Centre for Statistics in Medicine,
Oxford, U.K.

Each participant read 107 CT colonography cases: 60 patients had 142
polyps and the remaining 47 had normal colons. The cases were first
read without the assistance of CAD, and then two months later, the
studies were read with the assistance of CAD (Medicsight ColonCAR=E2=84=A2).
The study found that readers detected significantly more polyps with
CAD than without. For example, with CAD 41 (68 percent) of the 60
patients with polyps were more likely to be detected by readers.

This effect was mostly a result of improved detection of polyps
measuring 9 mm or smaller in maximal diameter. Importantly, specificity
was not adversely affected by CAD =E2=80=94 while sensitivity increased
significantly in seven readers, specificity declined significantly in
only one.

The study also investigated a concurrent read paradigm, where the CAD
annotated and un-annotated images are presented to the reader
simultaneously. The investigators found that this approach shortened
reader interpretation time significantly when compared to CAD
unassisted interpretation: by 1.9 minutes for patients with polyps and
by 2.9 for those without. Overall, nine (90 percent) of the readers
benefited when using CAD, either due to increased sensitivity,
decreased interpretation time, or a combination of both.

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