Problem using multiple port groups on a WS-X6716-10GE

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We are trying to add a load balancer to a 10GE port on a WS-X6716-10GE on a
 Cisco 6509E switch. When the load balancer is online, we experience strang
e issues and I'm starting to suspect it may be a configuration issue on the
 X6716.

All port groups on the X6716 are in oversubscription mode. Currently, only  
port 5, in port group 2, is in use. The load balancer is being added to por
t 1, in port group 1. As soon as the load balancer's port is configured, th
e issues start, even before traffic starts flowing to it. Is there some iss
ue we might be running into using multiple port groups?

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